home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9406b.zip
/
M9460269.TXT
< prev
next >
Wrap
Text File
|
1994-06-12
|
2KB
|
35 lines
Document 0269
DOCN M9460269
TI Anti-lipopolysaccharide antibody levels in patients with AIDS at the
onset of Pseudomonas aeruginosa bacteremia.
DT 9408
AU Kumar PN; Collins MS; Pierce PF; Division of Infectious Diseases,
Georgetown University Hospital,; Washington, D.C.
SO J Acquir Immune Defic Syndr. 1994 Jun;7(6):587-91. Unique Identifier :
AIDSLINE MED/94231463
AB Lipopolysaccharide (LPS) in the cell wall of the P. aeruginosa is a
major factor in the pathogenicity and virulence of this organism.
Immunotype-specific serum antibodies to this LPS antigen (ALPS) are
usually elevated with the onset of the bacteremia, act as opsonins, are
protective in high levels, and are significantly associated with
improved survival. In the present study, the ability of 11 patients with
AIDS to mount a specific ALPS response with the onset of P. aeruginosa
bacteria was evaluated prospectively. Of the 11 patients with AIDS only
one had a substantial ALPS response, six mounted only a marginal ALPS
response, and four had no ALPS response to the infecting strain of the
P. aeruginosa. These data suggest most patients with AIDS do not exhibit
a marked antigen-specific humoral response at the onset of P. aeruginosa
bacteremia; this has important prognostic and therapeutic significance,
as high ALPS titers are associated with survival.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY/ MORTALITY
Adult Antibodies, Bacterial/BLOOD Bacteremia/COMPLICATIONS/*IMMUNOLOGY
Female Human IgG/BLOOD Lipopolysaccharides/*IMMUNOLOGY Male Middle
Age Opsonins/IMMUNOLOGY Prognosis Prospective Studies Pseudomonas
aeruginosa/*IMMUNOLOGY Pseudomonas
Infections/COMPLICATIONS/*IMMUNOLOGY/MORTALITY Risk Factors Support,
Non-U.S. Gov't Survival Rate JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).